Speaker 1: Barbara Sahakian, UK

s | 23 forced swimming test, and antidepressant effects were attenuated by local injection of NBQX into the mPFC, indicating that both an mGlu2/3 receptor antagonist and ketamine exert the effects through AMPA receptor stimulation in the mPFC. In addition, we found that depletion of serotonin blocked antidepressant effects induced by local injection of LY341495 or ketamine into the mPFC. We also found that both compounds increased the c-Fos expression in the serotonin neurons in the dorsal raphe nucleus (DRN), which was blocked by local injection of NBQX into the mPFC, suggesting that both compounds may activate subsets of serotonin neurons in the DRN regulated by AMPA receptor stimulation in the mPFC. These studies revealed that mGlu2/3 receptor antagonists exhibited similar antidepressant profiles with ketamine in animal models in that they exerted rapid and sustained effects and were effective in animal models refractory to current medications. Moreover, mGlu2/3 receptor antagonists may share mechanisms underlying antidepressant effects with ketamine at both synaptic and neural levels. Therefore, mGlu2/3 receptor antagonists may be useful as an alternative approach to treating patients with TRD. Other agents including GLYX-13 and GluN2B antagonists which could be alternatives to ketamine will also be briefly discussed. CP02: Anxiety Title: Clinical perspective of Anxiety Disorders in Korea Speaker 1: Dan Stein, South Africa Speaker 2: Kang-Seob Oh, Republic of Korea Abstract Since 21st century, anxiety disorders(Generalized Anxiety disorder, Panic Disorder, Social Anxiety disorder) are no more ignorant in Korea. Many studies including epidemiologic, clinical characteristic, and treatment studies of anxiety disorders were published in Korea. In this session, the speaker will present about prevalence rate of anxiety disorders, clinical characteristics of anxiety disorders, and treatment results studies of anxiety disorders in Korea. The speaker will also introduce some treatment guidelines of anxiety disorders in Korea.Since 21st century, anxiety disorders(Generalized Anxiety disorder, Panic Disorder, Social Anxiety disorder) are no more ignorant in Korea. Many studies including epidemiologic, clinical characteristic, and treatment studies of anxiety disorders were published in Korea. In this session, the speaker will present about prevalence rate of anxiety disorders, clinical characteristics of anxiety disorders, and treatment results studies of anxiety disorders in Korea. The speaker will also introduce some treatment guidelines of anxiety disorders in Korea.